故事舞台是在现代的意大利都市,政府机关“社会福祉公社”表面上是收容重伤残障的少女给予医治和帮助职业训练的福利机构,但实际上是将收容的少女加以义体改造并投入药物加以洗脑制约使其成为对抗恐怖份子的尖兵。每位少女都搭配一位辅佐官,而这组合称为“fratello”是意大利语中“兄妹”之意,每位少女对其辅佐官都有制约造成的混合了爱情及亲情的绝对忠诚。跟社会福址公社敌对的恐怖组织是被称为“五共和国派”的组织。该组织的政治诉求,是响应以意大利北部为据点的“北部同盟”(Lega Nord)党首Umberto Bossi所提倡,意大利北部8省与中部3省(包括托斯卡纳(Toscana),翁布里亚(Umbria),马尔凯(Marche))应该自意大利共和国分离独立的主张,并依此实行武装抗争运动的组织(但在现实中的意大利并无此组织,真实存在的北部同盟也不支持恐怖活动)。
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